现代癌症护理时代的患者和医生JAMA,
SCI
22February
PatientsandPhysiciansintheEraofModernCancerCare
SledgeGW.PatientsandPhysiciansintheEraofModernCancerCarePatientsandPhysiciansintheEraofModernCancerCarePatientsandPhysiciansintheEraofModernCancerCare..
CorrespondingAuthor:GeorgeW.Sledge,MD,StanfordUniversitySchoolofMedicine,CCSR-,CampusDr,Stanford,CA(gsledge
stanford.edu).Cancercarehasundergonearevolution,drivenbyadvancesintheunderstandingofcancerbiologyandnewtherapeuticsderivedfromthatunderstanding.Manypatientsdiagnosedashavingcancerinthesreceivedrelativelyineffective,toxicchemotherapeutics.Today,apatientencounteringanoncologistmightundergoatumorbiopsywiththegoalofevaluatinghundredsofoncogenicmutations.Thatpatientthenreceivesoneofthemanytargetedtherapeutics(eg,kinaseinhibitors,monoclonalantibodies)orimmuno-oncologyagentsintheever-expandingtherapeuticarmamentarium,manydevelopedwithinthepastdecade.
在癌症生物学理解的进步和源于这种理解的新疗法的推动下，癌症治疗经历了一场革命。许多在20世纪90年代被诊断患有癌症的患者接受了相对无效的有毒化学治疗药物。如今，在肿瘤科就诊时的患者可能会接受肿瘤活检，以评估数百种致癌突变。然后该患者在过去十年内开发的、不断扩大的治疗设备中，接受多种靶向治疗（例如，激酶抑制剂，单克隆抗体）或免疫肿瘤药物中的一种进行治疗。
Thesediagnosticandtherapeuticrevolutionshaveimprovedout
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