对癌症筛查检查的依从性与癌症无关因素
SCI
3Janurary
AssociationofNonadherencetoCancerScreeningExaminationsWithMortalityFromUnrelatedCausesASecondaryAnalysisofthePLCOCancerScreeningTrial
Pierre-VictorD,PinskyPF.AssociationofNonadherencetoCancerScreeningExaminationsWithMortalityFromUnrelatedCauses.JAMAinternalmedicine.
CorrespondingAuthor:PaulF.Pinsky,PhD,DivisionofCancerPrevention,NationalCancerInstitute,MedicalCenterDr,Room5E,Bethesda,MD(pp4f
nih.gov).IMPORTANCE重要性
Patientnonadherencetochronicdiseasepreventionguidelinesisassociatedwithincreasedmortality.Nonadherencetoofferedcancerscreeningtestsmaybeassociatedwithmortalityamongmiddle-agedandolderadults.
患者不依照慢性病预防指南治疗会使死亡率增加。不依从规范的癌症筛查项目可能与中老年人的死亡率有关。
OBJECTIVE目标
ToevaluatetheassociationbetweennonadherencetocancerscreeningtestsandmortalityintheProstate,Lung,ColorectalandOvarian(PLCO)CancerScreeningtrial,excludingmortalityfromcancersstudiedinthetrial.
排除试验中研究的癌症本身的死亡率，评估前列腺癌、肺癌、结直肠癌和卵巢癌(PLCO)癌症筛查试验中不依从规范癌症筛查的检查与死亡率之间的关系。
DESIGN,SETTING,ANDPARTICIPANTS设计，设置和参与者
Randomizationat10USscreeningcentersoccurredfromNovember8,,toJuly2,.Originalfollow-upwasthrough13yearsorDecember31,.Participantswerere-consentedtofurtherfollow-upstartingMay18,,andwereobserveduntilDecember31,.ProtocolscreeningtestsforthePLCOCancerScreeningtrialinterventionarmparticipants(N=)includedchestradiographsandflexiblesigmoidoscopyforbothsexes,prostate-specificantigentestsanddigitalrectalexaminationsformen,andcancerantigentestsandtransvaginalultrasonographyforwomen.
将年11月8日到年7月2日之间美国10个筛查中心的数据进行了随机化。第一次试验的随访时间为13年或截至年12月31日。参与者再次同意从年5月18日开始进一步随访到年12月31日。拟定的对PLCO癌症筛查试验试验组受试者(N=)的癌症筛查检查项目包括男性和女性的胸部x线片和软性乙状结肠镜检查、男性的前列腺特异性抗原检查和直肠指诊检查、女性的癌症抗原检查和阴道超声检查。
Atbaseline,participants
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